Scientific journal

52 2013

Journal of Food and Nutrition Research
Summary No. 3 / 2013

Arai, K. – Yamazaki, T. – Tokuji, Y. – Kawahara, M. – Ohba, K. – Hironaka, K. – Kinoshita, M. – Ohnishi, M.
Effects of Chinese yam storage protein on formation of aberrant crypt foci in 1,2-dimethylhydrazine-treated mice
Journal of Food and Nutrition Research, 52, 2013, No. 3, s. 139-145

Mikio Kinoshita, Department of Food Science, Obihiro University of Agriculture and Veterinary Medicine, Inada-cho, Obihiro, Hokkaido 080-8555, Japan; United Graduate School of Agricultural Sciences, Iwate University, Morioka, Iwate 020-8550, Japan. Tel.: +81-155-49-5545, Fax+81-155-49-5549, e-mail:

Summary: The effects of Chinese yam (Dioscorea opposita Thunb.) dietary storage protein on the formation of 1,2-dimethylhydrazine (DMH)-induced aberrant crypt foci (ACF) were investigated in large intestines of mice. Feeding with Chinese yam storage protein resulted in significant suppression of DMH-induced ACF formation in all mice examined. Dietary yam and yam storage protein suppressed aberrant crypt (AC) growth and significantly increased terminal deoxynucleotidyl transferase dUTP nick end labelling (TUNEL) positive cell numbers in large intestines. An in vitro study showed that the digestion products of yam storage protein induced cellular apoptosis. In agreement with this finding, the present study also clearly demonstrated that DMH-induced ACF formation was inhibited by dietary yams. Hence, daily ingestion of yams may suppress colon carcinomas in humans.

Keywords: yam (Nagaimo); aberrant crypt foci; colon cancer; 1,2-dimethylhydrazine; storage protein

  (pdf, 294.96 Kb, 1479x)