Scientific journal

52 2013

Journal of Food and Nutrition Research
Summary No. 3 / 2013

Sousa, I. J. B. – Matias, E. F. F. – Menezes, I. R. A. – Coutinho, H. D. M.
Modulation of the antibiotic activity by the essential oils of Origanum vulgare and Coriandrum sativum
Journal of Food and Nutrition Research, 52, 2013, No. 3, s. 191-194

Henrique D. M. Coutinho, Laboratory of Microbiology and Molecular Biology, Department of Biological Chemistry, University of the Region of Cariri – URCA, Rua Cel. Antônio Luis, 1161, Pimenta, Crato (CE), Brasil. Tel.: +55(88)31021212; fax: +55(88) 31021291, e-mail:

Summary: Medicinal plants had been used by traditional populations as a way to treat diseases for centuries. Currently, despite the search of the pharmaceutical industry for different kinds of drugs, the bacterial mechanisms of resistance against antimicrobial drugs are a real problem to the health. Origanum vulgare and Coriandrum sativum are medicinal plants with essential oils of a known antibacterial activity. The essential oils were assayed for their antibacterial and modulatory antibiotic activities by gaseous contact method. Both essential oils demonstrated modulatory activity mainly when associated with gentamicin and vancomycin. These natural products demonstrated an interesting potential to be studied in association with antibiotics to elaborate new drug formulations, or to be used as functional foods.

Keywords: Origanum vulgare; Coriandrum sativum; gaseous contact; vancomycin; gentamicin; ciprofloxacin

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