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Journal of Food and Nutrition Research
Súhrny čísla 3 / 2026
Zhang, Y.
Dietary supplementation with selenium-enriched yeast protects the liver from beta-cypermethrin
Journal of Food and Nutrition Research, 65, 2026, č. 3, s. 243-255
Yi Zhang, College of Life Sciences, Nankai University, Weijin Road 94, 300071 Tianjin, China. E-mail: yizhang0113@163.com
Original article
Received 22 January 2026; 1st revised 1 July 2026; accepted 28 July 2026; published online 17 August 2026
DOI: https://doi.org/10.64122/VMPU8870
Súhrn: Beta-cypermethrin (β-CYP) is a widely used insecticide for pest control in both indoor and outdoor settings, but its persistent low-dose toxicity poses potential risks to human health. In this study, we investigated the hepatoprotective activity of selenium-enriched yeast (Se-yeast), a prevalent organic selenium dietary supplement, against β-CYP-induced hepatic injury. In vitro, HL7702 cells exposed to 200 μg·ml-1 β-CYP were treated with 22.56 mg·l-1 Se-yeast, with assessments of cell viability, DNA integrity, apoptotic rate and cell cycle distribution. In vivo, mice administered 40 mg·kg-1 β-CYP received 42.86 mg·kg-1 Se-yeast; hepatic antioxidant enzyme and aminotransferase activities, liver index, histopathological features and related protein expression were analysed. β-CYP induced DNA damage, G1-phase cell cycle arrest, decreased cell viability and increased apoptosis in HL7702 cells. In murine models, β-CYP elevated hepatic aminotransferase activities and reduced the activities of antioxidant enzymes. Se-yeast treatment almost completely abrogated these deleterious effects, upregulating P70S6K expression and downregulating p53, caspase-3 and LC3 expression in β-CYP-exposed mouse liver. Our findings demonstrate that Se-yeast exerts significant hepatoprotection against β-CYP toxicity by promoting cell proliferation, enhancing antioxidant capacity and suppressing apoptosis and autophagy.
Kľúčové slová: selenium-enriched yeast; beta-cypermethrin; liver injury; protective effects
Na stiahnutie:
jfnr-2026-3-pp243-255-zhang.pdf (PDF, 1.04 Mb, 121x)